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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TNNI3K All Species: 9.09
Human Site: S847 Identified Species: 20
UniProt: Q59H18 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.4
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q59H18 NP_001106279.1 936 104179 S847 S L S P S S S S D C L V N R G
Chimpanzee Pan troglodytes XP_513493 949 105567 S860 S L S P S S S S D C L V N R G
Rhesus Macaque Macaca mulatta XP_001097254 949 105560 S860 S L S P S S S S D C L V S R G
Dog Lupus familis XP_537112 1087 119299 M998 C L C N I E L M S P A S S N S
Cat Felis silvestris
Mouse Mus musculus Q5GIG6 834 92569 D746 L S P S S S S D C L L S R G G
Rat Rattus norvegicus Q7TQP6 835 92713 D747 L S P S S S S D C L L S R G G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001339957 835 92821 D747 L S P S S S T D C L A A R G S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_001021182 850 93167 A762 I L S L I P Q A W H P E S S S
Sea Urchin Strong. purpuratus XP_782227 862 95496 D774 V L S M L D A D W A T P I D D
Poplar Tree Populus trichocarpa XP_002336079 539 60951 I451 A D V F S F G I V L W E L L T
Maize Zea mays NP_001152032 543 61643 V455 D V F S F A I V L W E L A T S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.2 96.5 80.1 N.A. 80.7 81.3 N.A. N.A. N.A. N.A. 75.7 N.A. N.A. N.A. 36.7 51.1
Protein Similarity: 100 98.3 97.2 82.6 N.A. 84.4 85.3 N.A. N.A. N.A. N.A. 83.7 N.A. N.A. N.A. 55 65.6
P-Site Identity: 100 100 93.3 6.6 N.A. 33.3 33.3 N.A. N.A. N.A. N.A. 13.3 N.A. N.A. N.A. 13.3 13.3
P-Site Similarity: 100 100 100 13.3 N.A. 33.3 33.3 N.A. N.A. N.A. N.A. 20 N.A. N.A. N.A. 26.6 20
Percent
Protein Identity: 23.6 22.4 N.A. N.A. N.A. N.A.
Protein Similarity: 37.2 36.2 N.A. N.A. N.A. N.A.
P-Site Identity: 6.6 0 N.A. N.A. N.A. N.A.
P-Site Similarity: 13.3 20 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 0 10 10 10 0 10 19 10 10 0 0 % A
% Cys: 10 0 10 0 0 0 0 0 28 28 0 0 0 0 0 % C
% Asp: 10 10 0 0 0 10 0 37 28 0 0 0 0 10 10 % D
% Glu: 0 0 0 0 0 10 0 0 0 0 10 19 0 0 0 % E
% Phe: 0 0 10 10 10 10 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 10 0 0 0 0 0 0 28 46 % G
% His: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % H
% Ile: 10 0 0 0 19 0 10 10 0 0 0 0 10 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 28 55 0 10 10 0 10 0 10 37 46 10 10 10 0 % L
% Met: 0 0 0 10 0 0 0 10 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 10 0 0 0 0 0 0 0 0 19 10 0 % N
% Pro: 0 0 28 28 0 10 0 0 0 10 10 10 0 0 0 % P
% Gln: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 28 28 0 % R
% Ser: 28 28 46 37 64 55 46 28 10 0 0 28 28 10 37 % S
% Thr: 0 0 0 0 0 0 10 0 0 0 10 0 0 10 10 % T
% Val: 10 10 10 0 0 0 0 10 10 0 0 28 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 19 10 10 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _